منابع مشابه
119 Enhancer of Zeste Homolog 2: A Pivotal Role in Pulmonary Artery Smooth Muscle Cell Proliferation
119 Enhancer of Zeste Homolog 2: A Pivotal Role in Pulmonary Artery Smooth Muscle Cell Proliferation Salman Aljubran, MD, Ruan Cox, Prasanna Tamarapu Parthasarathy, 3 Richard F. Lockey, MD, and Narasaiah Kolliputi, PhD,. Allergy and Immunology, University of South Florida, Tampa, FL; Internal Medicine, University of South Florida, Tampa, FL; University of South Florida, Tampa, FL; Division of A...
متن کاملImpact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis
Enhancer of zeste homolog 2 (Ezh2) has been shown to play a role in the differentiation of T helper (Th) 1 and 2 cells in mice studies using Ezh2-deficient T cells. However, the results have been inconsistent, and the function of Ezh2 in human Th1 and Th2 cell differentiation and its association with disease remains controversial. We measured the expression of Ezh2 in Th1 and Th2 cells in perip...
متن کاملEnhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells.
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that includes noncatalytic subunits suppressor of zeste 12 (SUZ12) and embryonic ectoderm development (EED). When present in PRC2, EZH2 catalyzes trimethylation on lysine 27 residue of histone H3 (H3K27Me3), resulting in epigenetic silencing of gene expression. Here, we investigated the expre...
متن کاملEnhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.
The intracellular RIG-I-like receptors recognize 5'-triphosphate viral genomic RNA and initiate the production of cytokines through mitochondria adaptor VISA. The regulation of this signal pathway is largely unknown. In this study, we report that the histone methyltransferase enhancer of zeste homolog 2 (EZH2) inhibits RIG-I signal pathway in an methyltransferase-independent manner. Knockdown E...
متن کاملEnhancer of Zeste Homolog 2 as an Independent Prognostic Marker for Cancer: A Meta-Analysis
BACKGROUND Novel biomarkers are of particular interest for predicting cancer prognosis. This study aimed to explore the associations between enhancer of zeste homolog 2 (EZH2) and patient survival in various cancers. METHODS Relevant literature was retrieved from PubMed and Web of Science databases. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calcula...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2012
ISSN: 1939-4551
DOI: 10.1097/01.wox.0000411864.66502.14